Zoloft is FDA approved to treat depression, social anxiety disorder, posttraumatic stress disorder (PTSD), panic disorder, obsessive-compulsive disorder (OCD), and premenstrual dysphoric disorder (PMDD) in adults over age 18. It is also approved for OCD in children and adolescents age 6-17 years.

For more than 15 years, Zoloft has safely and effectively treated millions of people with depression and anxiety. And Zoloft is available in multiple strengths, so your doctor can decide a dose for you.

What is Zoloft and what does it do?

Zoloft® (sertraline HCl) is a prescription medicine that treats depression and anxiety. It belongs to a class of drugs known as SSRIs (Selective Serotonin Reuptake Inhibitors). Zoloft works to correct a chemical imbalance in the brain that may be related to symptoms of depression or anxiety. It has been prescribed to millions of people for over 15 years. What medical conditions is Zoloft approved to treat? The Food and Drug Administration (FDA) approved Zoloft for the treatment of a number of mood and anxiety disorders including depression, social anxiety disorder, posttraumatic stress disorder (PTSD), panic disorder, obsessive-compulsive disorder (OCD) and premenstrual dysphoric disorder (PMDD) in adults over age 18. It is also approved for OCD in children and adolescents age 6-17 years. How long does it take to feel better with Zoloft? Every person is unique. The time it takes to feel better is different for everyone. Some of your symptoms might start to improve within one to two weeks or it could take up to eight weeks. Even if you don’t feel better right away, it’s important to keep taking your medicine as directed. Give Zoloft a chance to work for you. How long will I have to take Zoloft? Length of treatment is different from person to person. The American Psychiatric Association (APA) recommends all medicines for depression should be taken for six months to one year in order to prevent symptoms from returning. Your doctor will decide how long you need to be on Zoloft. It’s important to keep taking Zoloft as directed. Even if you feel better, you shouldn’t stop taking Zoloft without talking to your doctor first.

Everyone gets depressed at one time or another and everyone has anxiety at one time or another. Sometimes we need to use medication to help resolve the anxiety and depression, but sometimes the cure is worse than the disease. Zoloft side effects include sleeplessness. I have bouts of insomnia, so Zoloft may really have a negative effect on me.

Other Zoloft side effects include nausea and diarrhea. That’s depressing in itself. In addition, the medication may interfere with sex drive. This would send my husband into a deep state of depression that no medication could fix. The makers of the anti-depressant also include anxiety and nervousness among the Zoloft side effects. Anxiety is what I’m trying to avoid.

My depression and anxiety do interfere with my daily routine on occasion. Some days I just want to stay in bed. Many times I have to call off work because I just feel fatigued and overwhelmed. I think that I may not be alone in that. Zoloft side effects would seem small if I were really suffering from anxiety and depression.

I guess that the best thing for me to do is consult my physician. I can consider Zoloft side effects and discuss it openly with my doctor. Who knows, maybe I’ll find that I just get a little down every once in awhile and I get a little anxious. I may discover that I am quite normal in that. Sometimes we make things out to be worse than they really are.

Is Zoloft Addictive?

Going by the usual definition of “addictive” it isn’t, but, yes, there are most definitely withdrawal symptoms when people don’t taper off gradually. Usually it’s called “discontinuation symptoms” rather than withdrawal, but it doesn’t make the symptoms any less bothersome. Usually it’s best to gradually lessen your dosage over time to minimize the symptoms. There are also reports that over the counter drugs like Benedryl can help with symptoms.

Why is Zoloft prescribed?
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Zoloft is prescribed for major depression—a persistently low mood that interferes with everyday living. Symptoms may include loss of interest in your usual activities, disturbed sleep, change in appetite, constant fidgeting or lethargic movement, fatigue, feelings of worthlessness or guilt, difficulty thinking or concentrating, and recurrent thoughts of suicide.

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Zoloft is also used to treat the following:

Premenstrual dysphoric disorder (PMDD), a condition marked by a depressed mood, anxiety or tension, emotional instability, and anger or irritability in the two weeks preceding menstruation.

Obsessive-compulsive disorder (unwanted thoughts that won’t go away and an irresistible urge to keep repeating certain actions, such as hand-washing or counting).

Panic disorder (unexpected attacks of overwhelming anxiety, accompanied by fear of their return).

Social anxiety disorder (extreme shyness in social situations that interferes with an individual’s work and social life).

Post-traumatic stress disorder (re-experiencing a dangerous or life-threatening event through intrusive thoughts, flashbacks, and intense psychological distress).

Zoloft belongs to a class of drugs called selective serotonin re-uptake inhibitors (SSRIs). Serotonin is one of the chemical messengers believed to govern moods. Ordinarily, it is quickly reabsorbed after its release at the junctures between nerves. Re-uptake inhibitors such as Zoloft slow this process, thereby boosting the levels of serotonin available in the brain.
Most important fact about Zoloft
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Do not take Zoloft within 2 weeks of taking any drug classified as an MAO inhibitor. Drugs in this category include the antidepressants Marplan, Nardil, and Parnate. When serotonin boosters such as Zoloft are combined with MAO inhibitors, serious and sometimes fatal reactions can occur. In addition, you should not combine Zoloft with the drug pimozide (Orap).
How should you take Zoloft?
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Take Zoloft exactly as prescribed: once a day, in either the morning or the evening.

Zoloft is available in capsule and oral concentrate forms. To prepare Zoloft oral concentrate, use the dropper provided. Measure out the amount of concentrate prescribed by your doctor and mix it with 4 ounces of water, ginger ale, lemon/lime soda, lemonade, or orange juice. (Do not mix the concentrate with any other type of beverage.) Drink the mixture immediately; do not prepare it in advance for later use. At times, a slight haze may appear after mixing, but this is normal.

Improvement with Zoloft may not be seen for several days to a few weeks. You should expect to keep taking it for at least several months.

Zoloft may make your mouth dry. For temporary relief suck a hard candy, chew gum, or melt bits of ice in your mouth.

* If you miss a dose…
Take the forgotten dose as soon as you remember. If several hours have passed, skip the dose. Never try to “catch up” by doubling the dose.

* Storage instructions…
Store at room temperature.

(sertraline, Pfizer)
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A selective serotonin reuptake inhibitor (SSRI) for treating posttraumatic stress disorder (PTSD), the first drug approved for this indication.

* Recommended Dosage: A starting dose of 50 mg once a day increasing to a maximum of 200 mg/day if necessary. In PTSD trials, patients were treated with 50-200 mg/day.

* Special Considerations: In these trials, Zoloft was safe and well tolerated, with side effects similar to those seen in studies of Zoloft for other indications. Beneficial effects seen largely in women only

* Comment: Approval was based on two civilian studies of predominantly female subjects with PTSD, which found that those treated with 50-200 mg of Zoloft a day had significant improvements in PTSD symptoms over 12 weeks versus those on placebo.

But no beneficial effects were seen in another study of predominantly female civilians and a fourth study of mostly male veterans. “The importance of this apparent gender difference is unknown,” the FDA said in a statement announcing that the drug had been approved.

One possibility brought up at a hearing in October where the FDA’s psychopharmacologic drugs panel backed this approval was that the type of trauma that leads to PTSD may affect treatment response: physical, sexual, or emotional abuse was the index traumatic event in the civilian trials, as opposed to combat-related trauma in the veteran study.

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Abstract: Panic is an often incapacitating and chronic disorder. Cognitive behaviour therapy (CBT) and Xanax have been shown to be effective in the treatment of panic disorder. Patients who met the DSM-III-R criteria for panic disorder, were randomized and given 16 weeks of double-blind treatment with CBT (n=16), or Xanax of up to 6 mg/day (n=18). The 17-item HAM-D and HAM-A scales were administered to all the subjects before and after treatment, which took place over 16 weeks, and the changes in the scores were analyzed. The patients’ anxiety levels and numbers of panic attacks were assessed at the beginning of treatment, and then at weeks 4,8,12 and 16 by means of self-monitoring. On the basis of HAM-D, HAM-A, anxiety level, and panic number, the CBT and Xanax groups showed a significant improvement at the end of treatment. When compared to each other, the groups showed no significant differences at the end of the treatment. In the last month, 10/16 (62.5%) of the CBT patients and 11/18 (61.1%) of the Xanax patients were panic-free. Key Words: Xanax, Cognitive behavior therapy, Panic disorder. Introduction Panic disorder is a common anxiety disorder associated with a great deal of distress as well as marked social and occupational disability (1,2). Such patients are over-represented with regard to the use of medical services, such as emergency room visits, the number of visits to physicians and the use of psychotropic medications (3,4,5,). In addition, their rate of attempted suicide has been reported to be either greater to that of the general population or equal to that of patients suffering from major depression (6,7,8). Clinical evidence suggests that cognitive-behaviour therapy (CBT) is an effective treatment for panic. For example, Gitlin et al. reported that 10 out of 11 patients receiving CBT were not panicking by the end of treatment (9). Beck, Ost, Craske have also reported nearly total elimination of panic in patients suffering from panic disorder using either cognitive behavioral or behaviorally- based relaxation treatments (10,11,12). In the 1980s, a new class of benzodiazepines, the triazolobenzodiazepines, became available. One member of that class, Xanax, has been reported to be effective in the treatment of panic disorder (13,14). To our knowledge, few reports have compared the efficiency of both treatment in patients with panic disorder. In view of the effectiveness of this CBT and of Xanax in panic disorder, the purpose of this study was to evaluate the effectiveness of each treatment.Buy Xanax Materials and Method Subjects: Patients were drawn from patients attending the psychiatry clinic. All had been given a diagnosis of panic disorder with mild or no agoraphobic avoidance, using DSM-III-R criteria. Only patients with at least four panic attacks within a four-week period, or those experiencing one or more attacks followed by a period of at least a month of persistent fear of another attack were included. The general exclusion criteria were as follows: age below 18 or above 65 years, current drug or alcohol abuse/dependency, principal diagnosis of major depression, and any signs of psychosis or organic brain syndrome. Finally, subjects were excluded if they had begun taking benzodiazepines or antidepressants within the previous six months. xanax and Cognitive Behavior Therapy in Treatment of Panic Disorder At the onset of treatment, the subjects comprised 40 patients with panic disorder. The patients were treated with either CBT or Xanax for two months, and then followed for two months without CBT and Xanax. Measures: Clinical assessment measures consisting of the Hamilton Anxiety Rating Scale (HAM-A) and the Hamilton Rating Scale for Depression (HAM-D) were administered to all subjects before and after treatment, and the changes in the scores were analyzed. A self-monitoring measure was administered at the beginning of treatment and assessed at 4-week periods throughout treatment. Patients monitored their current levels of anxiety on a 0-to-8-point visual analogue scale, four times a day (morning, afternoon, evening and bedtime), stating whether or not they experienced panic (patients were instructed and trained to define and differentiate a panic attack from episodes of generalized anxiety). The data from the visual analogue scale served to measure the anxiety level and panic number Xanax treatment group: Patients received 1mg doses of Xanax (1 or 2 mg) up to four times daily. Medication was gradually increased until the maximum benefit was achieved or dose-limiting side effects occurred. Patients began taking one tablet per day (for two days) and then this was increased to two tablets (for three days), three tablets (for four days), four tablets (for four days), five tablets (for four days), and then six tablets per day on day 18. When side effects were reported, these increases in medication were slowed or the dose was reduced. Every effort was made to achieve a dosage of six tablets per day. Patients were given an explanation of their condition, including what could be expected of the medication. No other centrally active medications were administered during the trial. At the beginning of the 9th week of treatment, the psychiatrist began to taper the doses of Xanax at a rate no faster than one tablet every 3 days. The psychiatrist continued meeting patients until they had stopped taking medication completely. CBT group: The treatment consisted of a 2-month course of CBT. The patients received 8 individual sessions of CBT for panic disorder in weekly meetings. Buy Xanax Exposure plus cognitive restructuring were applied in the case of these patients. Treatment comprised a rationale and education concerning panic disorder, the components of anxiety and emphasized exposure to somatic cues. Cognitive approaches were also included. In cognitive therapy, we helped the patients to identify and modify their negative thoughts. In addition, the patients were encouraged to expose themselves to situations or activities which they were avoiding. They were also encouraged to modify behaviours which occur once symptoms have started and which maintain a patient’s belief that certain symptoms are highly dangerous. Results Out of 40 initial patients, 34 patients completed the study, and 6 patients dropped out. A higher rate of drop out was observed in the CBT group than in the other group. Two patients out of 20 (10%) dropped out of the Xanax group, while 4 out of 20 (20%) dropped out of the CBT group. A t-test analysis on these dorp-out frequencies showed no significant differences between the CBT and Xanax group (t=1.03,p=0.314). Patients who dropped out of the study were questioned about their reasons. Of the 4 patients who dropped out of the CBT group, 2 developed intense panic attacks in the 1 st week of the treatment, causing them to drop out of the study. Two were unavailable for interview after the second week of treatment. The 2 subjects who dropped out of the Xanax treatment group stated that they disliked the side effects of the medication in the 1 st week of treatment (1 reported over-sedation, and 1 reported suicidal ideation). In the CBT group, 9 men (56%) and 7 women (43%) completed the study. Buy Xanax The mean age was 30.81 years. In the Xanax group, 6 men (44%) and 12 women (56%) completed the study. The mean age was 31.44 years. The mean age difference between the groups was not significant (F=0.574, df=32, t=-0.234, p>0.05). In the CBT group (16 patients), the mean score on the Hamilton Depression Scale at week 0 was 12.06 (range, 2 to 45), with only 5 patients (31.2%) scoring values above 14. In the Xanax group (18 patients), the mean score on the Hamilton Depression Scale at week 0 was 10.83 (range, 2 to 40), with only 6 patients (33.3%) scoring in the range above 14. In the study intake, no statistical difference between the two groups in the average HAM-D and HAM-A scores were found using the Mann-Whitney test (z=-0.657, p>0.528), (z=-0.346, p>0.746).

Xanax and DN-2327 (Pazinaclone) in humans: Psychomotor, memory, subjective, and reinforcing effects.

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Abstract The psychomotor, memory, subjective, and reinforcing effects of DN-2327 (DN), a novel partial agonist at benzodiazepine receptors, were compared with those of Xanax (AL) in 14 men with histories of sedative drug abuse. Placebo, DN (8, 16, and 32 mg), and AL (0.5, 1.0, and 2.0 mg) were administered orally in a randomized, double-blind, cross-over design. DN and AL produced similar maximal impairment on psychomotor and memory performance. AL produced greater increases in participant ratings of sedation and a variety of somatic symptoms that were absent following DN. Abuse liability measures showed both drugs increased liking and good effects and were categorized by participants as sedative-hypnotics; however, 2 of 3 indirect and 1 direct measure of drug reinforcement were greater with AL than with DN. The dissociation between psychomotor-memory performance effects and various subjective effects demonstrates a novel pharmacological profile of DN. (PsycINFO Database Record (c) 2007 APA, all rights reserved)

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Xanax is an addictive recommendation medicine that slows down the central nervous system. Xanax is as well recognized as benzodiazepines. It is an anti-panic and anti-anxiety medication. Xanax is helpful to ease tenseness, nervousness, and worry related with nervousness disorders.
It works by affecting the part of the brain that controls the emotions, thereby slowing down the nervous system.
Symptoms of Xanax Patients
Generally, it is characterized by unrealistic worry, illusion, mystification, hopelessness, rash, itchiness, sore throat, vision changes, dry mouth, etc.

Side Effects Of Xanax

Xanax has some side effects, if you take overdose of it. The side effects of exceeding Xanax dosages are sleepiness, susceptibility, vibration, state of unconsciousness, coma, problem in inhalation; closing of your throat; swelling of your lips, mouth, etc. At this time patient needs emergency treatment at once.

Storage Of Xanax Medicine
Xanax should be kept at room temperature. Also Xanax should be stored away from humidity and warmth. Last but not the least keep Xanax out of the reach of kids.

Withdrawal Of Xanax
Xanax is habit-forming. If patient suddenly discontinue xanax treatment then it would cause withdrawal swymptoms. Therefore, If you are allowing for stopping Xanax treatment, concern your doctor for advice. So that, you can stop xanax treatment safely without any problem.

Precautions
Elderly and debilitated patients, or those with organic brain syndrome, have been found to be prone to the CNS depressant activity of benzodiazepines even after low doses. Manifestations include ataxia, oversedation and hypotension. Therefore, medication should be administered with caution to these patients, particularly if a drop in blood pressure might lead to cardiac complications. Initial doses should be low and increments should be made gradually, depending on the response of the patient, in order to avoid oversedation, neurological impairment and other possible adverse reactions.

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Alprazolam should not be administered to individuals prone to drug abuse. Caution should be observed in all patients who are considered to have potential for psychological dependence. Withdrawal symptoms have been observed after abrupt discontinuation of benzodiazepines. These include irritability, nervousness, insomnia, agitation, tremors, convulsions, diarrhea, abdominal cramps, vomiting and mental impairment. Since these symptoms may be similar to those for which the patient is being treated, it may appear that he has suffered a relapse upon discontinuation. It is suggested that alprazolam should be withdrawn gradually if the individual is suspected of having become dependent, or the drug perhaps has been used in prolonged high doses.

Suicidal tendencies may be present in patients with emotional disorders, particularly when depressed and that protective measures and appropriate treatment may be necessary and should be instituted without delay.

Alprazolam should not be used in patients suspected of having psychotic tendencies since excitement and other paradoxical reactions can result from the use of anxiolytic-sedatives in these patients. As with other benzodiazepines, alprazolam should not be used in individuals with physiological anxiety or normal stress of daily living but only in the presence of disabling manifestations of an appropriate pathological anxiety disorder.

These drugs are not effective in patients with characterological and personality disorders or those with obsessive compulsive disorders. Alprazolam is not recommended for the management of depressive or psychotic disorders.

If treatment is necessary in patients with impaired hepatic or renal function, therapy should be initiated at a very low dose and the dosage increased only to the extent that it is compatible with the degree of residual function of these organs.

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If alprazolam is administered for repeated cycles of therapy, periodic blood counts and liver function tests are advisable. Back to top of page

Since benzodiazepines may occasionally exacerbate grand mal seizures, caution is required when used in epileptic patients and an adjustment may be necessary in their anticonvulsive medication. Abrupt withdrawal of alprazolam should be avoided.

Benzodiazepines may potentiate or interact with effects of other CNS acting drugs such as alcohol, narcotics, barbiturates, nonbarbiturate hypnotics, antihistamines, phenothiazines, butyrophenones, MAO inhibitors, tricyclic antidepressants and anticonvulsants. Therefore, if alprazolam is to be combined with other drugs acting on the CNS, careful consideration should be given to the pharmacology of the agent involved because of the possible additive or potentiating effects. Patients should also be advised against the simultaneous use of other CNS depressant drugs and should be cautioned not to take alcohol during the administration of alprazolam.

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Panic Disorder
XANAX is also indicated for the treatment of panic disorder, with or without agoraphobia.
Studies supporting this claim were conducted in patients whose diagnoses corresponded
closely to the DSM-III-R/IV criteria for panic disorder (see CLINICAL STUDIES).
Panic disorder (DSM-IV) is characterized by recurrent unexpected panic attacks, ie, a discrete
period of intense fear or discomfort in which four (or more) of the following symptoms
develop abruptly and reach a peak within 10 minutes: (1) palpitations, pounding heart, or
accelerated heart rate; (2) sweating; (3) trembling or shaking; (4) sensations of shortness of
breath or smothering; (5) feeling of choking; (6) chest pain or discomfort; (7) nausea or
abdominal distress; (8) feeling dizzy, unsteady, lightheaded, or faint; (9) derealization

(feelings of unreality) or depersonalization (being detached from oneself); (10) fear of losing
control; (11) fear of dying; (12) paresthesias (numbness or tingling sensations); (13) chills or
hot flushes.
Demonstrations of the effectiveness of XANAX by systematic clinical study are limited to 4
months duration for anxiety disorder and 4 to 10 weeks duration for panic disorder; however,
patients with panic disorder have been treated on an open basis for up to 8 months without
apparent loss of benefit. The physician should periodically reassess the usefulness of the drug
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